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Previous studies reported that the presence of curcuminoids is associated with anti-inflammatory capacity, which is attributed to a reduction in lipid peroxidation, inhibition of the binding of the transcription factor NF-B (nuclear factor kappa B) to DNA, leading to a decrease in pro-inflammatory cytokine concentrations, as well as a reduction in circulating inflammatory levels of gamma interferon and inhibition of COX-1 (cyclooxygenase-1 enzyme), COX-2 (cyclooxygenase-2 enzyme), and LOX activities (7, 13, 53, 58)

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The authors demonstrated the utility of this approach by optimizing a four-gene heterologous pathway involved in biosynthesis of the terpene linalool ( 172 )

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