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[86] studied a model of chronic cerebral hypoperfusion in adult rats caused by permanent ligation of both common carotid arteries

Hoyles L, Pontifex MG, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, et al

doi: 10.1016/j.tem.2016.09.002

Not all endurance athletes refer to the use of supplements, but an estimated 2030 billion dollars are spent on supplements each year in the United States and athletes of all levels are more likely to experiment with supplements compared to non-athletes (7, 15)
