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An increase in NF-B activity and its target gene expression and a decrease in anti-inflammatory GATA3 and cytokine expression were observed after Compound C or si-Mfn2 application

In the hippocampus, adult neurogenesis occurs in the subgranular zone of the dentate gyrus (111, 112) and is a complex process that involves the proliferation of neural stem cells and progenitor cells (Type 2a, 2b and 3 cells) (113115), the differentiation of neuroblasts into granular neurons through the stadium of immature granular neurons (IGNs), and the integration of new neurons into preexisting circuits in the dentate gyrus (116, 117)