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Description
The illness is characterized by gradual loss of dopaminergic neurons in the substantia nigra and the appearance of Lewy bodies, which include aggregation of alpha-synuclein, extensively dispersed proteins in the cerebral tissues
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Furthermore, comparing to patients with normal renal function, the prevalence of hyperhomocysteinemia and the resulting death caused by atherosclerotic vascular disease are substantially greater in ESRD patients (6)
We have previously shown that the TPN solution is directly toxic to the liver, and that this toxicity appears to be mediated by one or more amino acids
