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Targeting MAO-B with small-molecule inhibitors: a decade of advances in anticancer research (20122024)
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For example, in hereditary leiomyomatosis and renal cell cancer (HLRCC), a high level of fumarate caused by genetic mutation of fumarate hydratase induces the succination of Kelch-like ECH-associated protein 1 (KEAP1) accompanied by the consumption of a fumarate molecule 134,135
doi: 10.1053/j.gastro.2013.02.043
