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Peer review Peer review information Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work

The endogenous sources of oxidants include cellular systems localized on the plasma membrane, in the cytosol, in the peroxisomes, and on membranes of mitochondria and endoplasmic reticulum

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Phylum-level analyses indicate predominant Firmicutes with relative Bacteroidetes reduction in some studies (264, 265), while others report increased Actinobacteria , Verrucomicrobia , or pro-inflammatory Proteobacteria , alongside potential reduction of beneficial Bacteroidetes and Actinobacteria ( 262, 266)