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eLife 10 , e64508 (2021)

Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22, 948, MY-5455, vinopectine and 1-methyl-3- isobutyl-8-(methylamino)xanthine

This poses a significant challenge considering that most of the nutrients will have a broad impact on the brain as they are essential building blocks as well as signaling molecules, acting often as co-factors in biochemical processes in the various cell types in our brain [12, 155] rather than targeting a specific brain region, or cell type

Chemical synthesis and biotransformation pathways of natural saponins are gradually discovered, which is helpful to enrich the structural diversity of saponins and develop promising compounds (Juang and Liang, 2020)