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Chronic HIV infection alone has been known to cause significant oxidative stress systemically, both in pre-clinical and clinical studies, and both GSH and Cys have been extensively studied in this population

10.1016/j.biopha.2016.03.048 Biomed Pharmacother

N-acetylcysteine may have a role in reducing the myocardial injury occurring in the post-COVID-19 syndrome

Mitochondrial glutamate is subsequently converted into alpha-ketoglutarate (-KG) by glutamate dehydrogenase 1 (GLUD1 or GDH1) or by several mitochondrial aminotransferases, including glutamic-pyruvic transaminase 2 (GPT2) and glutamic-oxaloacetic transaminase 2 (GOT2)