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Timothy Garvey, a lead investigator in the trials, noted that the findings are directly relatable to clinical practice precisely because of that flexibility

It is hypothesized that changes in gut microbiota can lead to a leaky gut, increasing intestinal permeability and allowing harmful pathogens, toxins, and microbial products to enter the bloodstream

Baylin SB, Ohm JE

In fact, calculation of the partial charge distribution on each atom of Cys and similar free amino acid sidechains using quantum mechanical approaches demonstrated that the polarity of this residue is quite similar to that of Ser, which is classified as a polar residue (Fig