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The euchromatin is characterized by an open state and is amenable to transcription, while the heterochromatin is characterized by a compact DNA-protein structure that cannot be transcribed (Jenuwein and Allis, 2001)

This is clinically relevant, as IGF-I is generally less reliable of a biomarker for screening adults above 60 years with GHD and is a better screening and diagnostic biomarker in GHD in subjects with disease onset in childhood or early adulthood (86)

Adequate basement membrane reconstruction is a prerequisite for organized skin regeneration as opposed to scar tissue formation

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