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As with emphysema models, other animal models of emphysema exacerbation involved genetic manipulation to generate animals with specifically altered genes that have been suspected in the development of this condition

Particular lesions presentation in the corresponding brain areas (i.e., cerebral and cerebellar cortex) likely reflect particular damaging effects (i.e., cerebellar cortex appears to be the most affected in the early course (Figure 9), cerebral cortex later less affected, microglial recruitment presented later)

Collins, Ruth-Anne Seerattan, Walter Herzog CARTILAGE.2024