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References 190 and 191 highlighted the potential clinical implications of vascular co-option for resistance to anti-angiogenic therapy in metastatic disease

Expanded MSCs at P3 were inferior to freshly isolated bone marrow mononuclear cells in chondrogenesis and cartilage repair, in parallel with decreased telomerase activity, changed chromosomal morphology, downregulated cell cycle, DNA replication and mismatch repair (MMR) pathways [69]

Prevention and Management : Always choose a qualified healthcare provider for injection administration in a sterile environment to minimize skin sensitivity

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