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Considering that heme oxygenase-1 (HO-1) gene KO and treatment with zinc protoporphyrin IX (a HO-1 inhibitor) reduced Fe + levels and ROS-mediated LPO in PR cells, it has been proposed that HO-1 is a critical modulator of PR ferroptosis induced by atRAL (108)
In general, consistent with preclinical studies, RSV supplementation (500 mg/day, P.O for 4 weeks) raised erythrocyte PPAR- and Sirt1 expression and serum TAC and attenuated the total/HDL cholesterol ratio in CHD patients with type 2 diabetes [198]

doi: 10.1111/j.1440-1819.2009.02015.x

COVID-19 infection: an overview on cytokine storm and related interventions
