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The Sugimoto 1995 study documented that copper ions inhibit type 1 5-alpha reductase by up to 90% in vitro, with 50% inhibition at 0.12 mcg copper/mL

The compound demonstrates exceptional target selectivity, with no inhibition of related methyltransferases (DNMT1, PRMT3, COMT) or NAD+ salvage enzymes (NAMPT, SIRT1) at concentrations up to 600 M

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