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Funding Statement This research received no external funding

Choo, E

Symptoms of Vitamin B12 Deficiency Extreme tiredness, headaches/migraines, indigestion, diarrhoea, loss of appetite, low energy and mood, muscle weakness, a sore or red tongue often with mouth ulcers, pins and needles, weakened vision

Note: unlike many other kinases, such as those involved in regulating glycogen metabolism, pyruvate dehydrogenase kinase is not regulated by cAMP levels, but rather by molecules that signal changes in the energy status of the cell and the availability of biosynthetic intermediates, ATP and NADH, and acetyl-CoA, respectively