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These analyses were used to assess long-term systemic and local toxicity
V.GrechkoA
The alkylation of 4-hydroxythalidomide with tert-butyl bromoacetate to obtain a carboxylic acid derivative in order to facilitate the binding to the amine-terminal linker, for example, was carried out by Lis group in order to synthesize different cereblon-based PROTACs promoting the degradation of the 20S proteasome subunit 5
