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One study [NCT05444244] implemented an online recruitment strategy based on a community registry, successfully enrolling 182 participants with dementia, including those with FTD, within 10 monthsa stark contrast to the zero participants recruited through traditional methods

Atencion Primaria 2004;34:509 (author reply 509)

Furthermore, APOE4-targeted replacement mice, carrying the human APOE4 allele (a known strong risk factor for developing late-onset AD), display significant depressive-like behaviors compared to APOE3 counterparts, especially under stress conditions (Fang et al., 2021

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