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A 2020 study 28 also showed that citicoline improves psychomotor vigilance, arousal, and visual working memory while also lowering oxidative stress compared with a placebo

On the basis of the results available up to date, the Global Initiative for Chronic Obstructive Lung Disease [119] recognizes that mucolytic and antioxidant drugs, such as NAC, can be used as an adjunct therapy to reduce the risk of acute exacerbation of COPD, but in a limited way due to the lack of robust randomized controlled clinical trials (level of evidence B)