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Oligomeric -syn binds DNA, inhibits topoisomerases, and induces DNA supercoiling and double-strand breaks (DSBs), activating PARP-1 [77]

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While clinical studies have been investigating specific antiinflammatory dietary patterns (e.g., omega3 supplementation) for their potential to reduce pain severity and improve quality of life in conditions like IBS [430] and fibromyalgia [431], mindbody practices, such as meditation, yoga, and tai chi that integrate gentle movement with breath regulation and meditative focus, have got support from evidence showing that they can lower circulating inflammatory markers, improve heart rate variability, and reduce widespread hyperalgesia, effectively targeting multiple pillars of the nociplastic pain phenotype through nonpharmacological means [320, 432, 433]