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In the presence of such heterogeneity, TrkB modified therapeutic agents, as well as the use of epigenetic modulator interventions may be part of the solution to restore neuroplasticity and slow disease progress [298]

This effect does not occur locally by acting on CB 1 receptors in the locus coeruleus
WNT5A--target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer
