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The increased release of adipocyte chemokines, including MCP1 and leukotriene B4 (LTB4), is responsible for the transport and increased accumulation of immune and adaptive immune cells in adipose tissue (47, 48)

In flies, activation of c-Jun N-terminal kinase (JNK) signaling in neurons increased lifespan, in part through FOXO-mediated transcription (Lee et al., 2009)