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Description

It is characterized by ROS-induced dissociation of the oxygen-sensitive kinase KEAP1, activating the NRF2 signaling pathway and caspase-8-dependent cell death [241, 242]

Reactive nitrogen species (RNS), particularly nitric oxide (NO), are generated via the reduction of nNOS, inducible NO synthase (iNOS), nitrate, and nitrite, and serve as key mediators of oxidative stress ( BL can neutralize both extracellular and intracellular nitrosation reactions (Figure 1)

NO is a hydrophobic gas molecule with a high diffusion coefficient but a short life-time mainly due to its rapid reaction with oxygen and multiple cellular components