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Description
PMID: 11735244
One of the main molecular pathologic mechanisms in this setting is represented by -synuclein aggregation in mitochondria, which leads to the production of reactive oxygen species (ROS) and induces activation of p38 MAPK, a MAP-kinase that triggers the phosphorylation of Drp1 (dynamin-related protein-1), which eventually leads to mitochondrial fission (Lev et al., 2006)
Vartak, Steffan M
Mazziotti, G., Angeli, A., Bilezikian, J
