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Reduced or conjugated curcumin forms, such as 4HC, 6HC, and curcumin sulfate, showed a diminished ability to inhibit cyclooxygenase-2 (COX-2) synthesis (108)
Cells (2019) 8(11):1460
Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Downs syndrome (TESDAD): A double-blind, randomised, placebo-controlled, phase 2 trial
Furthermore, copper deficiency impairs the activity of certain Cu/Zn-oxides, which may lead to increased accumulation of ROS and oxidative stress, which further promotes inflammation and atherosclerosis (104)
