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In fact, GIP may be an even more potent insulin secretagogue than GLP-1 under certain conditions
Moreover, peptides have the ability to target specific flat pockets on molecules, areas that are considered unreachable by conventional small-molecule drugs

Both non-CG methylation and some CG methylation seem to be enriched on transcribed strands, yet, the relevance of such asymmetric methylation is currently unknown (Inoue and Oishi, 2005