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One argument against IF is that, despite the plethora of animal data, some human studies have failed to show such significant benefits of IF over CR.(54) Adherence to fasting interventions has been variable, some short-term studies have reported over 90% adherence,(54) whereas in a one year ADMF study the dropout rate was 38% vs 29% in the standard caloric restriction group.(135) There are many reasons some individuals experience difficulties adhering to IF regimens, but most notably is the fact that very few studies ensured that the switch was truly flipped and ketosis was achieved

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Funding statement We acknowledge support from National Institute of Health: T32AG000266-23 (KK), R01AG038688 (PK), AG045835 (PK), and the Larry L