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14 LRP5/6 are coreceptors of Wnts and are located on the plasma membrane
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Clarifying whether autophagy acts protectively or destructively in the context of CIO is crucial for developing targeted interventions
This recent preclinical study showed that the metabolism of racemic ketamine to (2 R ,6 R )-HNK is necessary for the antidepressant effects of ketamine, and that this metabolite itself shows antidepressant-like effects in mice that seem to be independent of the NMDAR
