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In the presence of differentiation stimuli, abnormal protein folding in the ER activates the unfolded protein response (UPR) signaling, which can be alleviated by global translational attenuation, induction of molecular chaperones, misfolded protein degradation by endoplasmic reticulum-associated degradation (ERAD), and apoptosis (63)

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For instance, in one study of early syphilis, all JHR cases occurred in patients receiving penicillin (57/170), whereas no cases were observed in the doxycycline-treated group (0/12) [21]

However, the use of -phycoerythrin in antioxidant assays has shortcomings for some reasons: -phycoerythrin has large variability in reactivity to ROO , leading to inconsistency in assay results