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This central disinhibition and facilitation are further compounded by neuroendocrine dysfunction (e.g., alterations in HPA axis function) and altered signaling of neurotrophins like brainderived neurotrophic factor (BDNF), which can promote synaptic plasticity and hyperexcitability

1,4 The presentation of bronchiectasis often overlaps with other respiratory conditions 5,6 Bronchiectasis initially presents with chronic cough and sputum production in addition to recurrent exacerbations

Zinc plays a major role in immune cell function

KPVs gut work runs through the oral PepT1 route
