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In females, activation of interferon- and cytokine-related pathways may reflect immune recalibration rather than generalized inflammation, consistent with emerging models of neuroinflammation as altered intercellular communication among neural cell types [5, 29-30]

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Individualized titration is essential to achieve serum trough levels in the mid-normal physiologic range, thereby minimizing adverse effects such as erythrocytosis, gynecomastia due to aromatization, or suppression of endogenous spermatogenesis

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