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Signs and Symptoms of Celiac Disease Gastrointestinal: Pain, bloating, gas Constipation and/or diarrhea Loss of appetite Nausea, vomiting Brain and nervous system: Recurring headaches Decreased sensation in peripheral nerves Anxiety, panic attacks Depression Other systems of the body: Fatigue Itchy skin rash (dermatitis herpetiformis) Unexplained infertility and miscarriage Iron-deficiency anemia and other nutritional deficiencies Arthritis Diagnosis of Celiac Disease Gold standard for diagnosis is a biopsy of the small intestine A more simple four-out-of-five guideline has been proposed: Typical symptoms of celiac disease (see Signs and Symptoms of Celiac Disease) Celiac disease immunoglobulin A antibodies are strongly positive in the serum HLA DQ2 and/or HLA DQ8 genes are present Characteristic changes are evident on small intestine biopsy Positive clinical response to a gluten-free diet Dietary and Lifestyle Changes Maintaining a gluten-free diet for life is essential for those with celiac disease