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557 Recent studies have found that the expression of HIF-2 may facilitate the maintenance of a pseudohypoxic state in cells, thereby promoting the onset and progression of diseases, including renal clear cell carcinoma, 558 pancreatic cancer, 559 and breast cancer

Removal of one or other axial ligands leaves cobalt in an intermediate cob(II)alamin state

The thyroid produces insufficient amounts of T3 or T4, which results in extreme fatigue, brain fog, weight gain, coarse hair and nails, hair loss, facial swelling, constant aches and pains, constipation, depression, poor sleep, and mood swings

Saccharolytic fermentation generates short-chain fatty acids (SCFAs) like acetate, propionate, and butyrate, which promote gut health and influence liver metabolism, potentially mitigating fat accumulation