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Titration: There is generally no need for upward titration with B-complex vitamins as one might do with certain drugs, but if a patient is frail or known to react to injections, the provider may choose to start at a lower dose (for example 0.25-0.5 mL) and then increase to 1 mL as tolerated

Other Possible Reactions to Vaccines Besides lumps, dogs can have other mild reactions to vaccines, like slight fever, lethargy, or reduced appetite

Other risk factors include certain gastrointestinal conditions, autoimmune conditions such as pernicious anaemia, long-term use of some medications, and increasing age

The pigment-producing skin cells are present but are not functional