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In terms of mitochondrial dynamics, excessive androgens are responsible for the decreased mitochondrial fusion and increased fission-induced fragmentation, as evidenced by the marked increase in Drp1 gene expression in the liver of mice with PCOS (135)

Tryptophan is decarboxylated to tryptamine by TDC, which then undergoes hydroxylation by a cytochrome P450 monooxygenase, forming serotonin (Schrder et al., 1999)

Yeon JE, Choi KM, Baik SH, Kim KO, Lim HJ, Park KH, Kim JY, Park JJ, Kim JS, Bak YT, Byun KS, Lee CH: Reduced expression of peroxisome proliferator-activated receptor-a may have an important role in the development of non-alcoholic fatty liver disease

doi: 10.1016/j.cell.2010.01.028 147 MartinetWDe MeyerGRAndriesLHermanAGKockxMM