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In addition, through various experimental studies, it was shown that ROS may trigger cardiac ectopic activity (25,26), because they affect (prolong) the action potential duration, causing early but also delayed post-depolarization and thus, the activity of aberrant fascicles

Concurrently, stress-activated signaling nodes such as GATA2/NF-B/STAT3 and Yes-associated proteins (YAP)/TEA domain (TEAD) reinforce survival through cross-talk with epigenetic modifiers, stabilizing DTP phenotypes [39, 41, 42] (Table 3)

Since beginning active grantmaking in 2008, Helmsley has committed more than $1.8 billion for a wide range of charitable purposes
Beyond laboratory science, longitudinal epidemiological studies incorporating biomonitoring and mechanistic endpoints will be crucial to establish causal links between internal exposure and health outcomes
