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Animal-to-human amount translation is not straightforward and requires allometric scaling, and human pharmacokinetics, safety, and efficacy remain uncharacterized in published literature

Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase

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However, this method faces significant challenges, as TAC is delayed relative to BAC and varies widely due to individual population differences in sweat gland density, sweat production, and other physiological factors (155)