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The following is one example of a titration schedule used in Phase 2 protocols it does not represent a single universal regimen, and other escalation speeds were also evaluated: Weeks 14: 2 mg once weekly (initiation dose) Weeks 58: 4 mg once weekly Weeks 912: 8 mg once weekly Week 13 onwards: 12 mg once weekly (where tolerated) This gradual up-titration mirrors the approach used with approved agents such as semaglutide and tirzepatide, where slow dose escalation is essential to improve gastrointestinal tolerability

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Lupus Erythematosus and Scleroderma are classified as vascular diseases, along with Polyarteritis Nodosa, and some other diseases, but Lupus and Scleroderma also have one other thing in common they can be treated in a similar manner with equally good results

Compounded medications are prepared by an FDA-registered pharmacy and are not FDA-approved drug products