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More research is needed to develop standard procedures that can differentiate between healthy and at-risk populations, including population-specific meal sizes, nutrient composition, blood sampling time points, and markers to measure, as OFTT methodology is still largely unstandardized

Furthermore, the increase in the content of TFAM, which controls mitochondrial DNA transcription and translation, remains in skeletal muscle one month after the withdrawal from chronic acetylcarnitine supplementation, indicating the long-lasting effect of acetylcarnitine on mitochondria [158]

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