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Oxidative stress is believed to significantly influence the pathogenesis of idiopathic infertility, being present in approximately 3040% of UMI patients and in up to 80% of IMI patients [28,238,239]

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In parallel, inflammatory responses are rapidly initiated, with activation of microglia, infiltration of peripheral immune cells, and production of pro-inflammatory cytokines like TNF- and IL-1, further exacerbating tissue damage (26)

Yzydorczyk C, Li N, Rigal E, Chehade H, Mosig D, Armengaud JB, Rolle T, Krishnasamy A, Orozco E, Siddeek B, Juvet C, Vergely C, Simeoni U (2019) Calorie restriction in adulthood reduces hepatic disorders induced by transient postnatal overfeeding in mice