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M., Haenlin, J

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While Rada 16 still has regenerative activity but mediated by a scaffold with integrins to adhere to cells (PRG and PDS) to promote proliferation, migration and production of extracellular matrix type I proteins and type III collagen from periodontal ligament fibroblasts in cell culture [34]

Yet, when sporadic AD occurs, the balance between the non-amyloidogenic and the amyloidogenic pathway becomes altered and, there is an excessive production of A, resulting from the cleavage of APP by the - and -secretase enzymes and a lower degradation of A due to a lower activity of the degrading enzymes previously mentioned, thus causing an imbalance between the production and elimination of A [3340]