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A routine B-12 shot can stabilize mood and serve as an effective measure to help prevent depressive relapses
As a result, the Food and Nutrition Board recommends that those over 50 get at least half of their daily allowance of B12 from fortified foods or supplements

Do vitamin D and B12 work together

J Postgrad Med 59(4):253 Kang D et al (2014) Higher prevalence of metformin-induced vitamin B 12 deficiency in sulfonylurea combination compared with insulin combination in patients with type 2 diabetes: a cross-sectional study
