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Further, the GSH cleavable linker was further attached to a recognition ligand to promote their specific accumulation in cancer cells

NRF2 also modulates inflammatory responses by inhibiting pro-inflammatory genes and mediates cell death pathways, including apoptosis and ferroptosis

Because 17-estradiol exerts an antidepressant-like action by its interaction with this receptor [78] and pomegranates also produce an anti-immobility effect in a short time [11], it is feasible that these receptors are also involved in the AE-PG actions