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The activation of the inflammasome and the secretion of IL-1 seem to be a major danger-sensing pathway to sterile inflammation and cardiac repair in several heart diseases 38

Transgenic mice with overexpression of glycogen synthase kinase-3 (GSK-3) show hyperactivity as observed in the manic phase of BD (Prickaerts et al., 2006)

10.1016/j.brainres.2010.10.016 166 ReinerA.LevitzJ

144 Moreover, H 2 O 2 enhances proteasome activity via S-glutathionylation of cysteine residues in the 20S subunit
