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In vitro studies have found that in IDH1 mutant glioma stem cells (TS603), the expression of genes related to ROS clearance is overall upregulated, and the gene that regulates glutathione synthesis, SLC7A11, is most upregulated

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Following SE, mGluR5 activation has also been shown to enhance astrocytic calcium signals during the latency period of epileptogenesis in the pilocarpine model of TLE (45)

Although its precise cause remains unclear, recent evidence suggests that metabolic disturbances, particularly oxidative stress and mitochondrial dysfunction, may play a significant role in the pathogenesis of the disease