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Additionally, it should not be administered in patients with subacute degeneration of the spinal cord

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Also, Ole inhibited myocardial infarction size and decreased creatinine kinase-MB and LDH serum levels in a myocardial ischemia/reperfusion rat model [202]

Estrogens and estrogen quinone metabolites can have the same damaging effects as ROS, alkylate, or damage the integrity of DNA and proteins, and also bind to estrogen receptors and activate estrogen response elements, which leads to increased levels of ROS [275]