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Concurrently, dynamic monitoring by leveraging liquid biopsies, multiomic profiling, and spatial transcriptomics will track realtime tumorimmune coevolution, reveal emergent resistance mechanisms, and guide early intervention before clinical progression occurs

Although chemical inhibitors have been shown to suppress DUX4 effects, further research is needed to build upon the new findings

Physiology 35, 302327

These CD8 + T cells subsequently migrate to the tumor bed in a stem-like state, where they undergo further restimulation within the TME and develop a canonical effector program to unleash cytotoxicity upon encountering tumor cells [144]
