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Kineman RD, Luque RM
In Nuclear Receptors: The Art and Science of Modulator Design and Discovery (Badr MZ, ed), pp
studies with insulin demonstrate that only about 12% of a peptide dose delivered through conventional buccal or sublingual routes reaches systemic circulation, highlighting the considerable barriers that remain for effective peptide delivery via the oral mucosa [33,68]
As a result, research teams often emphasize controlled observation, standardized reporting practices, and structured data collection procedures
