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Direct nicotine binding to nicotinic acetylcholine receptors on BECs induces acetylcholine-dependent nitric oxide (NO) release via activation of neurovascular endothelial NO synthase (Mazzone et al., 2010)
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The hot flashes some users report represent another blood pressure-relevant effect
Ice or over-the-counter anti-inflammatory medications, such as ibuprofen, can resolve any residual pain
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