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Although these findings do not conclusively rule out SARS-CoV-2 infection of the CNS, the evidence suggests that it is unlikely and neurological manifestations of infection may be largely due to systemic inflammatory responses to infection, as well as peripheral organ injury

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Dysbiosis of the gut microbiota reduces the activity of bile salt hydrolase and 7-dehydroxylase, leading to a decrease in free primary bile acids and an abnormal proportion of secondary bile acids

Initial loading protocols often use daily or every-other-day dosing for the first one to two weeks, followed by weekly, then monthly maintenance