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Chronic ethanol consumption alters mammalian gastrointestinal content metabolites
Sep 2013;8(3):255-287
IGF1R autophosphorylation also recruits Shc, which leads to Grb2/SOS/Ras activation and downstream ERK1/2 phosphorylation

In addition, the disruption in gut microbial community composition that often occurs in response to enteric pathogens, as well as environmental and genetic factors, is also associated with impaired gut barrier integrity